{"id":140,"date":"2022-04-16T03:40:37","date_gmt":"2022-04-16T03:40:37","guid":{"rendered":"https:\/\/mathimmunelab.works\/?page_id=140"},"modified":"2022-04-16T03:49:43","modified_gmt":"2022-04-16T03:49:43","slug":"indrani-nayak","status":"publish","type":"page","link":"https:\/\/mathimmunelab.works\/index.php\/people\/indrani-nayak\/","title":{"rendered":"Indrani Nayak"},"content":{"rendered":"\n
\"Indrani<\/figure>
Indrani Nayak<\/span>

Postdoctoral Scientist<\/p><\/div><\/div>\n\n\n\n

Lab member since : September 2021
Prior Institution : Indian Institute of Technology Bombay, India
Research Interest :
Natural killer (NK) cells are part of our innate immune system. They are a type of white blood cell that fights against pathogens and tumor cells via the interplay of its different activating and inhibiting receptors.
CD16 is one of the activating receptors that plays an important role in facilitating antibody-dependent cell-mediated cytotoxicity (ADCC) to
kill the target cells. In contrast to humans, CD16 receptors in mice have a poor response to target cells. Recent work has shown that the performance of the CD16 receptor in BWZ cells can be improved by
mutating the transmembrane domains of a specific adaptor protein CD3z. This results in mice having human-like responses, which could allow researchers to use this mouse model as a test subject for further
immunotherapy research. We investigate the signaling process by modeling the signaling pathways for CD16 in various CD3z mutants
using chemical kinetics, a system of ordinary differential equations, and stochastic simulations to analyze the downstream signals of molecules that participate in the signaling process.
We are also trying to understand how cytokines regulate NK cell proliferation and receptor expressions to enhance the therapeutic potential of the NK cell in in-vitro experiments.
Different dosages and mixtures of cytokines result in dintinct NK cell proliferation and receptor expression. We use linear regression model to understand the influence of various combinations of cytokines on NK proliferation and receptor expression. We aim to  find the optimal cytokine combination that boosts NK proliferation and activating receptor expression in order to enhance the cytotoxicity of the NK cells.
About Me :
I have grown up in West Bengal, India. My background is in Physics. I did my bachelor\u2019s degree from Visva Bharati University, Santiniketan, India. I earned my master\u2019s degree from Indian Institute of Technology
Guwahati, India, and joined Ph.D. program at the Department of Physics, Indian Institute of Technology Bombay, India. My doctoral dissertation focuses on stochastic processes, particularly first passage time statistics of a moving target under confined geometry. I used techniques of stochastic simulation (Langevin, Kinetic Monte Carlo) and theory (Master equation, Diffusion equation, Extreme value Statistics) for my doctoral work.
I love to travel, cook, and paint. I have recently started playing Ukulele.
Google Scholar link<\/a>
Research Gate link<\/a>
Linkedin<\/a>
Website<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Lab member since : September 2021Prior Institution : Indian Institute of Technology Bombay, IndiaResearch Interest :Natural killer (NK) cells are part of our innate immune system. They are a type of white blood cell that fights against pathogens and tumor cells via the interplay of its different activating and inhibiting receptors.CD16 is one of the … <\/p>\n

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